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Chemotherapy combined with involved-field radiotherapy for early-stage Hodgkin lymphoma: effects on outcome and long-term complications

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Author:: No author available

Journal Title:: JOURNAL OF LEUKEMIA & LYMPHOMA

Issue:: 8

DOI:: 10.3760/cma.j.issn.1009-9921.2010.08.004

Key Word:: 霍奇金病;受累野;放射疗法,计算机辅助;Hodgkin disease;Involved-field;Radiotherapy,computer-assisted

Abstract： Early-stage Hodgkin Lymphoma(HL) is curable by extended-field radiotherapy alone. To reduce the long-term toxicities and complications with similar overall survival, randomized controlled trials of combined-modality therapy have been investigated nearly two decades. Recent years, many large-scale randomized controlled trials showed superior disease-free survival of combined-modality treatment compared with radiotherapy or chemotherapy alone for early-stage classical HL. Thus, short-course chemotherapy plus involved-field and low-dose radiotherapy is the standard treatment for early-stage HL. With this regimen,several studies have been proved that long-term complications had been reduced, but long-time results should be awaited.

Reference

[1]Fisher SG,Schwartz C,Ng A,etc.Subsequent malignancies in children treated for Hodgkin's disease: associations with gender and radiation dose.[J].2008,72(1).
[2]Connors JM,Burns BF,Horning SJ,etc.Randomized comparison of ABVD chemotherapy with a strategy that includes radiation therapy in patients with limited-stage Hodgkin's lymphoma: National Cancer Institute of Canada Clinical Trials Group and the Eastern Cooperative Oncology Group.[J].2005,23(21).
[3]Higgins CD,Smith P,Horwich A,etc.Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study.[J].2007,99(3).
[4]A. AVILES,S. DELGADO.A prospective clinical trial comparing chemotherapy, radiotherapy and combined therapy in the treatment of early stage Hodgkin‘s disease with bulky disease[J].1998,20(2).
[5]Krol AD,Peny AM,Thomas J,etc.Combined-modality therapy for clinical stage I or II Hodgkin's lymphoma: long-term results of the European Organisation for Research and Treatment of Cancer H7 randomized controlled trials.[J].2006,24(19).
[6]Kung FH,Schwartz CL,Ferree CR,etc.POG 8625: a randomized trial comparing chemotherapy with chemoradiotherapy for children and adolescents with Stages I, IIA, IIIA1 Hodgkin Disease: a report from the Children's Oncology Group.[J].2006,28(6).
[7]Radford J,Lorigan P,Howell A,etc.Lung cancer after treatment for Hodgkin's lymphoma: a systematic review.[J].2005,6(10).
[8]Gray RG,Clarke MJ,Peto R,etc.Influence of more extensive radiotherapy and adjuvant chemotherapy on long-term outcome of early-stage Hodgkin's disease: a meta-analysis of 23 randomized trials involving 3,888 patients. International Hodgkin's Disease Collaborative Group.[J].1998,16(3).
[9]Kasper CE,McNeil DE,Stovall M,etc.Stroke As a Late Treatment Effect of Hodgkin's Disease: A Report From the Childhood Cancer Survivor Study.[J].2005,23(27).
[10]S A, Rosenberg,H S, Kaplan.The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin's disease: 1962-1984.[J].1985,11.
[11]R T, Hoppe.Hodgkin's disease: complications of therapy and excess mortality.[J].1997,8 Suppl 1.
[12]Specht L,Bogatyreva T,Brillant C,etc.Second malignancy risk associated with treatment of Hodgkin's lymphoma: meta-analysis of the randomised trials.[J].2006,17(12).
[13]Schnittger I,Strauss HW,Heidenreich PA,etc.Screening for coronary artery disease after mediastinal irradiation for Hodgkin's disease.[J].2007,25(1).
[14]Green DM,Sklar CA,Boice JD Jr,etc.Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study.[J].2009,27(14).
[15]Gockerman JP,Prosnitz RG,Koontz BF,etc.Combined-modality therapy versus radiotherapy alone for treatment of early-stage Hodgkin's disease: cure balanced against complications.[J].2006,24(4).
[16]Chronowski GM,Younes A,Cox JD,etc.Analysis of in-field control and late toxicity for adults with early-stage Hodgkin's disease treated with chemotherapy followed by radiotherapy.[J].2003,55(1).
[17]Martin WG,Witzig TE,Ansell SM,etc.Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin's lymphoma.[J].2005,23(30).
[18]Robison LL,DeLaat C,Fossati Bellani F,etc.High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group.[J].2003,21(23).
[19]Hull MC,Pepine CJ,Mendenhall NP,etc.Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of hodgkin lymphoma treated with radiation therapy.[J].2003,290(21).
[20]Horwich A,Swerdlow AJ.Second primary breast cancer after Hodgkin's disease.[J].2004,90(2).
[21]Ferme C,Eghbali H,Meerwaldt JH,etc.Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease.[J].2007,357(19).
[22]Palace A,Croft AP,Taylor AJ.Risk of thyroid cancer in survivors of childhood cancer: results from the British Childhood Cancer Survivor Study.[J].2009,125(10).
[23]Pukkala E,van Leeuwen-FE,Wiklund T,etc.Second cancers among long-term survivors of Hodgkin's disease diagnosed in childhood and adolescence.[J].2000,18(12).
[24]Howell SJ,Hopwood P,Kennedy J,etc.The UK national breast cancer screening programme for survivors of Hodgkin lymphoma detects breast cancer at an early stage.[J].2009,101(4).
[25]R, Zittoun,A, Audebert,B, Hoerni,etc.Extended versus involved fields irradiation combined with MOPP chemotherapy in early clinical stages of Hodgkin's disease.[J].1985,3.
[26]M, Henry-Amar.Second cancer after the treatment for Hodgkin's disease: a report from the International Database on Hodgkin's Disease.[J].1992,3 Suppl 4.
[27]Sparidans J,De Bruin ML,van't Veer MB.Breast cancer risk in female survivors of Hodgkin's lymphoma: lower risk after smaller radiation volumes.[J].2009,27(26).
[28]R T, Hoppe.Radiation therapy in the management of Hodgkin's disease.[J].1990,17.
[29]Mauch PM,Ng AK.The impact of treatment on the risk of second malignancy after Hodgkin's disease. Oncology/ESMO[J].2006,17(12).
[30]Vassilakopoulos TP,Boussiotis VA,Tsaftaridis P,etc.Combination chemotherapy plus low-dose involved-field radiotherapy for early clinical stage Hodgkin's lymphoma.[J].2004,59(3).
[31]Mauch P,Kun LE,Marcus KJ,etc.Unilateral and bilateral breast cancer in women surviving pediatric Hodgkin's disease.[J].2008,72(1).
[32]S, Pavlovsky,M, Maschio,M T, Santarelli,etc.Randomized trial of chemotherapy versus chemotherapy plus radiotherapy for stage I-II Hodgkin's disease.[J].1988,80.
[33]Joachim, Yahalom.Breast cancer after Hodgkin disease: hope for a safer cure.[J].2003,290(4).