Research progress of myeloproliferative disorders: several clinical problems post the JAK2 mutation era

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TIAN Ding(Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China)
ZHU Ping()
SHEN Jian-liang()
WANG Zhao()
Journal Title:
Volume 19, Issue 01, 2010
Key Word:
Myeloproliferation disorders; Gene, JAK2; Mutation; Diagnosis; Therapy

Abstract: This critical review was summarized more systematically about the JAK2V617F mutation of related research progress in myeloproliferative disorders (MPD) research fields and the identification of JAK2V617F mutation represents an important advance in our understanding of MPD was agreed. The authors focused on several sensitive problems of post the JAK2 mutation era, and expressed their opinions. The Guideline of the MPD diagnostic criteria recommended by WHO in 2008 was accepted. The authors recommend the MPD, rather than myeloproliferative neoplasm (MPN). The treatment for the MPD (not including the CML) is recommended. Before the effective targeting of JAK2V617F specific inhibitors for the treatment of the MPD, short-term of use hydroxyurea (HU) was suggested to suppress excessive proliferation of bone marrow of MPD and a long course of treatment application of inteferon-α(IFN-α), and low-dose of aspirin in a timely manner were recommended to prevent thrombosis and other complications.

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