Study on irregulatory modification of histone acetylation, methylation in diffuse large B-cell lymphoma

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Author:
YANG Yu-qing(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
MA Xu-dong(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
HUANG Yi-qun(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
ZOU Zong-kai(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
SHEN Hong-wu(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
Volume 18, Issue 10, 2009
DOI:
10.3760/cma.j.issn.1009-9921.2009.10.007
Key Word:
Lymphoma, large cell, diffuse; Histone; Methylation; Acetylation

Abstract: Objective To investigate the expression of histone acetylated H3 and H4, methylated H3K4 and H3K9 in diffuse large B-cell lymphoma (DLBCL). Methods The expression of histone acetylated H3 and H4, methylated H3K4 and H3K9 were examined by SP immunohistochemistry technique in lymphoid tissue of 40 cases with DLBCL and 16 cases with proliferative lymphadenitis. Results The expression of histone acetylation of H3 and H4 were lower than that in proliferative lymphadenitis. Histone methylated H3K4 was lower in expression and H3K9 was in higher expression. There was a positive correlative expression between the global histone acetylation of H3 and H4, the global histone acetylation of H3, H4 and histone methylation of H3K4. Conclusion Improper modification of histone acetylations and methylations may play an important role in pathogenesis in DLBCL.

  • [1]Lyko F,Brow R.DNA methyltransferase inhibitiors and the development of epigenetic cancer therapies.J NaH Cancer Ivst,2005,97:1498-1506.
  • [2]Geiman TM,Robertson KD.Chromatin remodeling,histone modifications,and DNA methylation-how does it all fit together? J Cell Biochem,2002,87:117-125.
  • [3]Minucci S,Nervi C,Lo Coco F,et al.Histone deacetylases:a common molecular target for differentiation treatment myeloid leukemias.Oncogene,2001,20:3110-3115.
  • [4]Yamaguchi Y,Kurokawa M,Imai Y,et al.AMLI is functionally egulated through p300-mediated acetylation on specific lysine residues.J Biol Chem,2004,279:15630-15638.
  • [5]Davis JN,McGhee L,Meyers S.The ETO (MTG8) gene family.Gene,2003,303:1-10.
  • [6]Hildebrand D,Tiefenbach J,Heinzel T,et al.Multiple regions of ETO cooperate in transcriptional repression.J Bio Chem,2001,276:9889-9895.
  • [7]Durst KL,Lutterbach B,Kummalue T,et al.The inv(16) fusion protein associates with coexpressors via a smooth muscle myosin heavy-chain domain.Mol Cel Bio,2003,23:607-619.
  • [8]Ma XD,Fang YQ,Beklemisheva A,et al.Phenybexyle isothiocyanate inhibits histone deacetylase and remodels chromation to induce growth arrest in human leukemia cells.Inter J Oncol,2006,28:1287-1294.
  • [9]黄轶群,马旭东,郑瑞玑,等.异硫氰酸苯己酯对Molt-4细胞组蛋白甲基化、乙酰化调控的实验研究.中华血液学杂志,2007,28:612-616.
  • [10]Bryant H,Farrell PJ.Signal transduction and transcription factor modification during reactivation of epstein-barr virus from latency.J Virol,2002,76:10290-10298.
  • [11]Wang L,Grossman SR,Kieff E.Epstein-Barr virus nuclear protein 2 interacts with p300,CBP,and PCAF histone acetyltransferases in activation of the LMPI promoter.Proc Nail Acad Sci U S A,2000,97:430-435.
  • [12]Musri MM,Corominola H,Casamitjana R.Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adipenectin promoter in preadipecytes.J Biol Chem,2006,281:17180-17188.
  • [13]Zegerman P,Canas B.Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex.J Biol Chem,2002,277:11621-11624.
  • [14]Lachner M,O'Carroll D,Rea S.Methylation of histone H3 lysine 9 creates a binding site for HPI proteins.Nature,2001,410:116-120.
  • [15]Kim KC,Geng L Huang S.Inactivation of histone methyltransferase by mutations in human cancers.Cancer Res,2003,63:7619-7623.
  • [16]Perters AH,O'carroll D,Scherthan H,et al.Loss of Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.Cell,2001,107:323-337.
  • [17]Soren JN,Robert S,Uta-Maria B,et al.Rb targets histone H3 methylation and HPI to promoters.Nature,2001,412:561-565.
  • [18]Pokholok DK,Harbison CT,Levine S,et al.Genome-widde map of nucleosome acetylation and methylation in yeast.Cell,2005,122:517-527.
  • [19]Wang H,Huang ZQ,Xia L,et al.Methylation of histone H4 at arginine facilitating transcriptional activation by nuclear hormone receptor.Science,2001,293:853-857.
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