Study on irregulatory modification of histone acetylation, methylation in diffuse large B-cell lymphoma

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YANG Yu-qing(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
MA Xu-dong(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
HUANG Yi-qun(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
ZOU Zong-kai(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
SHEN Hong-wu(Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China)
Journal Title:
Volume 18, Issue 10, 2009
Key Word:
Lymphoma, large cell, diffuse; Histone; Methylation; Acetylation

Abstract: Objective To investigate the expression of histone acetylated H3 and H4, methylated H3K4 and H3K9 in diffuse large B-cell lymphoma (DLBCL). Methods The expression of histone acetylated H3 and H4, methylated H3K4 and H3K9 were examined by SP immunohistochemistry technique in lymphoid tissue of 40 cases with DLBCL and 16 cases with proliferative lymphadenitis. Results The expression of histone acetylation of H3 and H4 were lower than that in proliferative lymphadenitis. Histone methylated H3K4 was lower in expression and H3K9 was in higher expression. There was a positive correlative expression between the global histone acetylation of H3 and H4, the global histone acetylation of H3, H4 and histone methylation of H3K4. Conclusion Improper modification of histone acetylations and methylations may play an important role in pathogenesis in DLBCL.

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