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Absence of Fanconi anemia proteins in acute myeloid leukemia cell lines THP-1 and M-07e

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Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
4
DOI:
10.3760/cma.j.issn.1009-9921.2008.04.003
Key Word:
白血病,髓样,急性;范可尼贫血互补群蛋白质类;基因组不稳定性;Leukaemia,myeloid,acute;Fanconi anemia complementation group proteins;Genomic instability

Abstract: Objective To find the possible relationship between defects in the FA/BRCA pathway of genomic maintenance and potential pathogenesis of acute myeloid leukaemia.Methods Twenty-five AML cell lines derived from diverse subtypes of AML were screened to investigate for possible defects in FA,BRCA patllway.Results The absence of FANCN protein in two cell lines,THP-1 and M-07e were observed,which was correlated with the results of MMC-induced G2 arrest,growth inhibition and chromosomal breakage test in both cell lines.But no gene aberrance in these two cell lines by MLPA test and DNA sequencing were found.Conclusion There is a possible relationship between defects in the FA/BRCA Dathway and potentialpathogenesis of acute myeloid leukaemia.A disturbance of the"FA pathway"may represent an early event in the development of this type of leukaemia.

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