You Position: Home > Paper

Experimental study on antileukemia effect of pachymaran in combination with selenium

( views:248, downloads:28 )
Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
2
DOI:
10.3760/cma.j.issn.1009-9921.2006.02.005
Key Word:
硒;茯苓多糖;抗小鼠白血病

Abstract: 目的研究硒协同茯苓多糖(CMP)对P388小鼠白血病的抗癌效果并探讨其治疗的分子机制.方法硒协同CMP治疗P388白血病模型,通过观察荷瘤小鼠生存期判断抑癌效果.采用原位杂交和免疫细胞化学技术检测淋巴细胞bcl-2基因;利用流式细胞术检测细胞凋亡、增生指数(PI)及细胞周期.结果CMP、硒与环磷酰胺联合用药使荷瘤小鼠生命延长75.09%;PI降低;bcl-2基因表达下调,凋亡指数增高,但凋亡率比单独环磷酰胺组低.结论CMP、硒与化疗药物合用后具有协同抗癌效应,能显著抑制癌细胞增生,下调bcl-2基因的表达、诱导癌细胞凋亡,从而延长荷瘤小鼠的生存期,同时减轻环磷酰胺的毒副作用.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn