You Position: Home > Paper
The study of relationship between epstein-barr virus and genomic imbalanced expression in lymphoma
( views:240, downloads:24 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2006.02.003
- Key Word:
- EB病毒感染;淋巴瘤;基因组
Abstract： 目的探讨EB病毒(EBV)感染与淋巴瘤基因组不平衡改变、临床表现、病理类型、疗效和预后的关系.方法免疫组化法检测EBV潜伏膜蛋白(LMP-1),原位杂交方法检测EBV编码的小RNA(EBERs)表达情况,比较基因组杂交(CGH)进行基因组水平不平衡改变的研究.结果EBV感染的霍奇金淋巴瘤(HL)和胃黏膜相关淋巴瘤(MALT)型基因组无不平衡改变.外周T淋巴细胞非霍奇金淋巴瘤(NHL)表现为基因异常的数目多,核型复杂,预后不良.大B细胞NHL、小B细胞NHL表现为基因组水平缺失与增益的数目少、化疗效果好.结论EBV感染后的NHL宿主细胞基因组水平改变,扩增与/或缺失数目多,临床表现呈进展性,化疗效果差,预后不良.
- [1]燕晓雯,石群立,孟奎,等.肠道淋巴瘤与EB病毒相关性研究[J].2002,(5).
- [2]高子芬,姜芬,潘增刚.p53基因突变与EB病毒相关性鼻咽部T细胞淋巴瘤[J].1999,(6).
- [3]刘淑云,顾依群,李宁,等.肠道淋巴瘤临床病理、免疫表型及与EB病毒相关性的研究[J].2003,(6).
- [4]J, Dierlamm,C, Rosenberg,M, Stul,etc.Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization.[J].1997,11(5).
- [5]G, Niedobitek.Patterns of Epstein-Barr virus infection in non-Hodgkin's lymphomas.[J].1995,175(3).
- [6]主编王毓銮, 米振国.现代非霍奇金淋巴瘤学[M].2003.
- [7]J D Fingeroth,M L Clabby,J D Strominger.Characterization of a T-lymphocyte Epstein-Barr virus/C3d receptor (CD21).[J].1988,62(4).
- [8]C A, Werner,H, D?hner,S, Joos,etc.High-level DNA amplifications are common genetic aberrations in B-cell neoplasms.[J].1997,151(2).
- [9]Shian-Min Liu M.D.,Kuan-Chih Chow Ph.D.,Chang-Fang Chiu M.D., Ph.D.,etc.Expression of epstein-barr virus in patients with hodgkin's disease in taiwan[J].1998,83(2).
- [10]P H, Rao,J, Houldsworth,K, Dyomina,etc.Chromosomal and gene amplification in diffuse large B-cell lymphoma.[J].1998,92(1).
- [11]王振义,陈竺.肿瘤的诱导分化和调亡疗法[M].1998.
- [12]沈志祥,1946.10-,欧阳仁荣.血液肿瘤学[M].1999.
- [13]Le-Beau MM,Ong ST.Chromosomal abnormalities and molecular genetics of non-Hodgkin's lymphoma.[J].1998,25(4).
- [14]卢大儒,邱信芳,薛京伦主编.医学分子遗传学[M].1998.
- [15]D A, Arber.Molecular diagnostic approach to non-Hodgkin's lymphoma.[J].2000,2(4).