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Analysis of twelve patients with hybrid acute leukemia
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-9921.2005.04.003
- Key Word:
- 急性混合细胞白血病;免疫分型;预后
Abstract： 目的分析急性混合细胞白血病(HAL)的临床和实验室特征以及疗效和预后.方法 根据骨髓细胞形态学、化学染色和免疫表型结果诊断HAL,评价疗效及影响疗效的相关因素.结果 12例HAL临床表现可有发热、淋巴结肿大、脾大、肝大、睾丸浸润等,所有患者骨髓增生明显活跃,近半数患者属高白细胞白血病.进行免疫表型检测者11例,B-Ly+/My+双表型8例、T-Ly+/My+双表型2例、B+T-Ly+/My+型1例.诱导化疗的总CR率64%,6例以兼顾粒、淋二系的方案治疗后全部CR,有4例巩固强化治疗后持续缓解,平均无病生存已19(16～24)个月.结论 HAL属特殊类型的白血病,其诊断有赖于对细胞形态学、化学染色和免疫分型的综合判断.对HAL的治疗应该给予兼顾粒、淋二系的诱导和巩固化疗方案.但长期疗效的评价还有待进一步观察.
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