You Position: Home > Paper
The study of angiogenesis in the bone marrow of leukemia patients
( views:169, downloads:4 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2005.02.005
- Key Word:
- 白血病;骨髓;血管新生;血管内皮生长因子
Abstract： 目的研究白血病患者的骨髓血管新生程度和骨髓液血管内皮生长因子(VEGF)水平的相关性.方法采用EnVison免疫组化法,用兔抗人vWF(yonWille-brand factor)多克隆抗体标记骨髓内皮细胞;采用ELISA法检测骨髓液中VEGF的含量.结果骨髓MVD在各实验组均明显高于正常对照组(P＜0.05).骨髓液VEGF水平在AML、CML组明显高于正常对照组(P＜0.01),ALL组与正常对照组比较差异无显著性(P＞0.05).对各白血病组的MVD和VEGF含量进行了相关性分析,结果表明在AML或CML组中VEGF水平和MVD呈正相关性(分别为r=0.648,P＜0.05;r=0.733,P＜0.05).结论白血病患者骨髓微血管数增多,提示血管新生在白血病发病中有重要作用,VEGF可能在一定程度上对血管新生有促进作用.
- [1]叶琇锦,王丽君,林茂芳,等.急性白血病患者骨髓血管新生的研究及临床意义[J].2003,(7).
- [2]A, Aguayo,H, Kantarjian,T, Manshouri,etc.Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes.[J].2000,96(6).
- [3]Angelo Vacca,Domenico Ribatti,Luisa Roncali,etc.Bone marrow angiogenesis and progression in multiple myeloma[J].1994,87(3).
- [4]张之南.血液病诊断及疗效标准[M].1998.