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ANALYZE THE CLINICAL MANIFESTATIONS AND PATHOLOGICAL FEATURE OF MULTICENTER CASTLEMAN DISEASE
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.05.005
- Key Word:
- 淋巴组织增生,非典型;Castleman病,多中心;病理;临床
Abstract： 目的:分析多中心Castleman病(MCD)的临床病理特点.方法:MCD患者5例,其中浆细胞型(PC)3例,透明血管型(HV)2例,均为男性,年龄43岁～62岁(中位年龄50岁).4例接受COP化疗,并分别应用糖皮质激素、沙利度胺+干扰素维持,1例放弃治疗.结果:临床情况5例分别不同程度表现发热、乏力、盗汗等非特异性全身症状,5例均存在多部位浅表淋巴结肿大,3例脾脏肿大.实验室结果:出现贫血及肾功能损害各有3例,4例患者出现多克隆高γ球蛋白血症,4例患者骨髓浆细胞或嗜酸粒细胞增多.治疗转归:1例4疗程COP治疗后生存8 a,2例治疗后迭PR,带病生存4个月、8个月,仍随访中.结论:多中心CD常累及多系统损伤,且表现较淋巴结肿大为早,PC型全身症状相对较重,致使MCD早期诊断存在困难,确诊须经淋巴结病理活检证实.
- [1]W B, Bowne,J J, Lewis,D A, Filippa,etc.The management of unicentric and multicentric Castleman's disease: a report of 16 cases and a review of the literature.[J].1999,85(3).
- [2]G, Frizzera.Castleman's disease and related disorders.[J].1988,5(4).
- [3]张之南.血液病诊断及疗效标准[M].1998.