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THE CLINICAL SIGNIFICANCE OF MULTIDRUG RESISTANCE GENE AND Topo Ⅱ EXPRESSION IN ACUTE LEUKEMIA
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.03.006
- Key Word:
- 白血病;多药耐药;TopoⅡ
Abstract： 目的:探讨急性白血病患者多药耐药基因(mdr1)和DNA拓扑异构酶Ⅱ(TopoⅡ)的表达及其临床意义.方法:采用反转录-聚合酶链反应(RT-PCR)技术检测了52例急性白血病患者mdr1基因和DNA拓扑异构酶Ⅱ的表达.结果:复发难治组白血病患者mdr1阳性率833%,明显高于初治组36.7%和完全缓解组10.0%.复发难治组TopoⅡ表达阳性率25.0%,低于初治组433%和完全缓解组70.0%.mdr1和TopoⅡ二者表达之间无相关性(P>0.05).mdr1(+)/TopoⅡ(-)者预后最差.结论:mdr1阳性和TopoⅡ的表达降低均是判断疗效和预后的重要指标.mdr1和TopoⅡ之间无相关性.
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