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THE CHARACTER AND SIGNIFICANCE OF IMMUNOPHENOTYPE IN 71 CASES OF ACUTE LEUKEMIA
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.02.005
- Key Word:
- 急性白血病;免疫表型;流式细胞术;预后
Abstract： 目的:分析急性白血病(AL)免疫表型特点及其临床意义.方法:采用单克隆抗体直接免疫荧光标记法的流式细胞术,对71例AL进行免疫表型检测.结果:71例AL患者以系列专一型表达为主,同时亦存在抗原交叉表达、不表达特异性抗原及混合型等情况.AL患者CD34和HLA-DR表达分别占563%和61.9%,M3患者均不表达HLA-DR.My+ALL患者完全缓解(CR)率(60.0%)低于My-ALL患者CR率(80.6%),两组相比有显著性差异(P＜0.05).CD+34ALL与CD+34ALL患者缓解率基本相同;CD+34AML患者CR率(583%)明显低于CD-34AML患者CR率(88.9%),两组相比有显著性差异(P＜0.05).结论:白血病免疫表型检测结合FAB分型可以提高诊断的准确率,部分免疫表型特征对判断预后有一定的意义.
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