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TREATMENT OF REFRACTORY ACUTE LEUKEMIA WITH CYCLOPHOPHAMIDE,Ara- C AND TOPOTECAN(CAT) REGIMEN
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2004.02.002
- Key Word:
- 拓扑替康;急性髓系白血病;难治性;化疗
Abstract： 目的:初步观察CAT(环磷酰胺、阿糖胞苷、拓扑替康)方案对难治性急性髓系白血病(AML)的近期临床疗效并评价此方案的不良副作用.方法:选择8例难治性AML(原发难治性AML3例,AML伴多系形态发育异常,此前有MDS病史患者3例,慢性粒细胞白血病AML变2例),应用CAT方案治疗,其中4例治疗1疗程,其余4例治疗2疗程.结果:1例在骨髓抑制期死于感染性休克,可评价疗效7例,1例达完全缓解(CR),3例达部分缓解(PR),1例CML急变患者经2疗程后回到慢性期,总有效率71.4%(5/7例),中位生存期为6.5(0.3～22+)个月.主要不良副作用为骨髓抑制.结论:CAT方案为高危MDS、加速/急变期CML和继发于MDS的AML患者的一个有效且毒性可耐受的治疗新方案.
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