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AMPLIFICATION OF C-erbB1 GERMLINE AND BM REPRODUCTION AND LEUKOMOGENESIS IN DIFFERENT ANEMIAS

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Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
6
DOI:
10.3760/cma.j.issn.1009-9921.2003.06.003
Key Word:
C-erbB1;胚系扩增;骨髓再生;白血病发生

Abstract: 目的:证明上皮生长因子受体(EGFR)基因与白血病发生和骨髓再生的相关性.方法:应用鸡原始红细胞增多症病毒癌基因V-erbB作探针,进行Southern印迹杂交,对8例不同贫血状态下的血液病,包括5例骨髓增生异常综合征(MDS),1例家族性急性髓细胞白血病及其亲属,1例缺铁性贫血(IDA)和1例范柯尼贫血(FA)等进行检测,并以7例AL、MDS和AA父母为对照.结果:MDS和AL有C-erbB1重排/扩增.患者父母仅有C-erbB1重排,大多数无胚系扩增;MDS和IDA有C-erbB1胚系扩增,但IDA无C-erbB1重排;正常人大多数与其父母一样,既无C-erbB1胚系扩增,也无C-erbB1重排.结论:C-erbB1即EGFR基因重排/扩增与MDS和AL有关,且其胚系扩增可能还与骨髓再生相关.白血病的发生还可能与骨髓再生有负相关,且对EGF不依赖.

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