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PROLIFERATIVE SIGNAL TRANSMISSION MEDIATED BY EpoR/H-RAS IN LEUKEMIC CELL LINES

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Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
1
DOI:
10.3760/cma.j.issn.1009-9921.2003.01.004
Key Word:
白血病;EpoR;H-Ras

Abstract: 目的:检测白血病细胞系红细胞生成素受体(EpoR)及H-Ras的表达,阐明EpoR/H-Ras介导的白血病细胞系HL-60、K562增生信号传导途径.方法:3H-TdR掺入法检测各细胞系对Epo刺激的增生反应;Western印迹法检测HL-60、K562细胞系中EpoR、H-Ras表达.结果:①HL-60、K562细胞系EpoR表达的阳性率分别为66%和61%.②HL-60、K562细胞系受Epo刺激而显著增生,同时伴有H-Ras显著增高,P<0.001.结论:白血病细胞系可有EpoR、H-Ras的表达;Epo可通过EpoR/H-Ras介导引起白血病细胞系的增生.

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