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Study on the Relationship Between Tumor Necrosis Factor Genetic Polymorphism and the Pathogenesis of Non-Hodgkin's Lymphoma

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Author:: No author available

Journal Title:: JOURNAL OF LEUKEMIA & LYMPHOMA

Issue:: 5

DOI:: 10.3760/cma.j.issn.1009-9921.2002.05.013

Key Word:: 非霍奇金淋巴瘤;肿瘤坏死因子;基因多态性

Abstract：目的：探讨肿瘤坏死因子α(TNFα)基因-308位和淋巴毒素(LTα)基因+252位基因多态性与非霍奇金淋巴瘤(NHL)发病的关系。方法：用聚合酶链反应(PCR)、限制性内切酶消化及电泳技术，对96例NHL患者和72名正常对照者的TNFα和LTα基因的单碱基突变多态性进行检测。结果：TNFα基因型和两个等位基因频率在对照组中的分布与NHL患者类似(P＞0.05)，而NHL患者的LTα(5.5)基因频率较对照组升高(NHL患者57.81％，正常人46.52％，P=0.04)。结论：TNFα基因多态性与NHL的发病无关，LTα(5.5)等位基因可能与中国汉族人NHL发病的易感性有关。

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