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Monitoritn Tthe bcr/abl Fusion on Peripheral Blood of Chronic Myeloid Leukemia Patients Treated by Interferon with duol-color Fluorescence in Situ Hybridization
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2002.03.006
- Key Word:
- 双色荧光原位杂交;慢性粒细胞性白血病;bcr/abl融合基因
Abstract： 目的：研究外周血双色荧光原住杂交(D-FISH)在慢性粒细胞性白血病(CML)患者干扰素治疗效果监测方面的应用价值。方法：用D-FISH方法对18例CML患者干扰素治疗前后的外周血36份样本进行bcr／abl融合基因检测，并且与骨髓D-FISH方法检测的结果进行比较。结果：治疗后外周血间期核细胞中bcr／abl融合基因的检出率较治疗前有所下降，并且外周血中的检出率比同一患者骨髓中的检出率要低。结论：D-FISH方法可以简便、灵敏、可靠地对CML患者干扰素治疗前后的外周血进行疗效监测，使得从取材上更加方便。
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