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Lymphoma of Mimicking Malignant Histiocytosis Clinical and Pathological Study of 6 Cases

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Author:: No author available

Journal Title:: JOURNAL OF LEUKEMIA & LYMPHOMA

Issue:: 3

DOI:: 10.3760/cma.j.issn.1009-9921.2002.03.003

Key Word:: 恶性组织细胞病;淋巴瘤;EB病毒

Abstract：目的：探讨酷似恶性组织细胞病(malignant histiocytosis，MH)的淋巴瘤之临床及病理学特征。方法：对曾确诊MH的6例患者临床、实验室有关指标进行分析；对尸检、活检病理标本采用单克隆抗体免疫组化染色、HE染色和EB病毒(epstein-barr virub，EBV)原位杂交(EBER-ISH)。结果：6例患者临床、实验室及细胞形态学酷似MH特征。尸检示：恶性细胞侵袭广泛，多中心分布不均匀。免疫表型分析：CD45RO+、CD3c+、CD20-、CD68-，提示恶性细胞属T细胞来源而非组织细胞来源。同时所作3例EBER-ISH均为阳性反应。结论：酷似MH的淋巴瘤其恶性细胞多来源于T细胞。EBV感染可能与发病有一定相关性。

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