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STUDY OF RELATION BETWEEN ALTERATION OF TELOMERSE ACTIVITY AND BLAST CRISIS OF CHRONIC MEYLOID LEUKEMIAS
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.01.007
- Key Word:
- 端粒酶;慢性粒细胞;端粒酶重复扩增法
Abstract： 目的:探讨端粒酶活性与慢性粒细胞性白血病(chronic myeloid leukemia,CML)急变之间的关系.方法:采用端粒酶重复扩增法(telomeric repeat amplification protocol,TRAP)探讨了15例正常人、43倒不同CML病人、12例相同病人不同时期端粒酶活性的改变.结果:端粒酶活性阳性率愈高,CML愈易引起急变,而且大部分病例端粒酶活性增高出现在急变之前.结论:端粒酶活性增高可能是引起CML急变的一个重要原因,在临床上动态检测端粒酶活性有助于预测CML病情进展.
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