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抗N-甲基-D-天冬氨酸受体抗体与神经精神狼疮
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- Author:
- No author available
- Journal Title:
- NATIONAL MEDICAL JOURNAL OF CHINA
- Issue:
- 37
- DOI:
- 10.3760/cma.j.issn.0376-2491.2010.37.019
- Key Word:
- No keyword available
Abstract： @@ 神经精神狼疮(NPSLE)是系统性红斑狼疮(SLE)的严重并发症,可以累及中枢神经、周围神经和自主神经系统,也可表现为多种精神症状[1].1999年美国风湿病学会(ACR)总结出NPSLE的分类及各自定义,将NPSLE分为19个临床亚型[2].NPSLE的发病机制尚不完全清楚,多数学者认为主要包括血管病变、自身抗体和炎症介质3个方面[3].其中自身抗体一直被认为在NPSLE的发病中起到了重要作用,目前所进行的研究也最为深入.抗磷脂抗体、抗核糖体P蛋白抗体、抗rRNP抗体等作为与NPSLE病情相关的抗体已经得到广泛证实.近年来,抗N-甲基-D-天冬氨酸(NMDA)受体抗体与NPSLE的相关性,尤其与认知障碍、抑郁状态之间的关联日益受到重视.
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