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干细胞循环及其潜在应用前景

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Author:: No author available

Journal Title:: NATIONAL MEDICAL JOURNAL OF CHINA

Issue:: 21

DOI:: 10.3760/j:issn:0376-2491.2003.21.025

Key Word:: No keyword available

Abstract： @@ 干细胞(stem cell)是胚胎发育过程中产生的或在个体成长中存留的一些能无限自我更新(self-renewing)并同时又能定向分化生成一系列组织的原始细胞.目前,据其来源分为胚胎干细胞和成体干细胞;按其分化能力分为全能干细胞(totipotent stem cell, TSC)和多能干细胞(multipotent stem cell, MSC).一般认为胚胎干细胞为全能干细胞,而成体干细胞则多为多能干细胞.而近年来发现成年动物体内几乎所有的组织都存在成体干细胞,并表现有跨胚层多系分化,甚至一个成体细胞可以重建一个完整的系统或个体,这一系列现象打破了细胞分化发育的定向性和不可逆性这一传统观念,并极大地拓展了干细胞的概念,使人们开始从宏观角度思索干细胞作为一个特殊细胞群体的生物学行为及生物学意义.

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