You Position: Home > Paper
The Clinical Significance of Dynamically Monitoring Serum Creatine Kinase BB Activities in Neonates with Hypoxic-ischemic Encephalopathy
( views:186, downloads:0 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF MISDIAGNOSTICS
- Issue:
- 12
- DOI:
- 10.3969/j.issn.1009-6647.2002.12.012
- Key Word:
- 肌酸激酶/血液;同工酶类/血液;脑缺血/酶学;脑缺氧/酶学
Abstract： 目的探讨缺氧缺血性脑病(HIE)新生儿血清脑型肌酸激酶同工酶(CK-BB)和心型肌酸激酶同工酶(CK-MB)的活性变化,以了解CK-BB和CK-MB对HIE患儿的检测价值.方法在出生后1～3 d检测HIE患儿CK、CK-BB、CK-MB活性,与正常新生儿作对比,分析各项指标与病情、转归、预后的关系.结果中度、重度HIE患儿血清CK-BB、CK与正常新生儿相比有显著性升高;重度组CK-MB比正常组显著升高.CK-BB活性迅速下降者,治疗有效,预后良好;CK-BB活力持续升高,患儿预后差, CK-MB升高患儿常伴有心肌功能损害.结论血清CK-BB是诊断HIE的可靠、特异性指标,动态监测新生儿CK-BB、CK-MB活性对病情估计、判断疗效及预后评估有重要价值.
- [1]R A, Bakay,A A, Ward.Enzymatic changes in serum and cerebrospinal fluid in neurological injury.[J].1983,58(1).
- [2]姚裕家,李顺品,李炜如,等.缺氧缺血性脑病血和脑脊液LDH、CK及同工酶分析和相关性研究[J].1999,(1).