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新视角--质子泵抑制剂及其体外抑制幽门螺杆菌作用研究进展
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- Author:
- No author available
- Journal Title:
- CHINESE GENERAL PRACTICE
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1007-9572.2005.11.041
- Key Word:
- 质子泵抑制剂;幽门螺杆菌;抑菌作用
Abstract： 胃质子泵H+-K+ATP酶的发现,为抗胃酸分泌新药的研究提供了新的可能.从1988年第一个质子泵抑制剂奥美拉唑问世,经10多年来的临床应用,已成为一类疗效高、耐受性好、副作用少的抗酸药物和联合治疗幽门螺杆菌感染的药物.由于奥美拉唑的巨大成功,推动了其衍生物的研究开发,新的质子泵抑制剂药品陆续上市.本文对质子泵、质子泵抑制剂及其作用特点以及质子泵抑制剂对幽门螺杆菌的抑制机制研究进展进行简要综述.
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