You Position: Home > Paper
乌司他丁对老年心脏瓣膜置换病人全身炎症反应的影响
( views:254, downloads:12 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF GERONTOLOGY
- Issue:
- 18
- DOI:
- 10.3969/j.issn.1005-9202.2009.18.015
- Key Word:
- 乌司他丁;体外循环;炎症反应
Abstract： 目的 探讨乌司他丁在体外循环期间人工机械瓣置换手术中对老年患者全身炎症反应的影响.方法 将20例老年单纯二尖瓣人工机械瓣置换病人随机分为对照组和实验组.实验组在麻醉诱导后开始恒速静脉输注乌司他丁6 000 U/kg(30 min内输完),然后以1 000 U·kg-1·h-1的速率持续静脉输注至手术结束;对照组则不使用乌司他丁.分别于麻醉诱导前(T1)、体外循环开始后1 h(T2)、体外循环停止后1 h(T3)、体外循环停止后24 h(T4)抽取动脉血,测定血浆肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-10(IL-10)浓度.结果 两组病人血浆TNF-α、IL-6和IL-10的浓度,在T2～T4各时点与体外循环前比较均明显增加(P＜0.05);T2～T4时点实验组血浆TNF-α和IL-6浓度明显低于对照组(P＜0.01), IL-10浓度明显高于对照组(P＜0.05).结论 乌司他丁能抑制体外循环过程中促炎细胞因子TNF-α和IL-6的释放,促进抗炎细胞因子IL-10的释放,从而减轻体外循环引起的全身炎症反应.
- [1]D E, Carney,C J, Lutz,A L, Picone,etc.Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass.[J].1999,100.
- [2]Li D,Shen Y,Wu H,etc.Ulinastatin attenuates lung ischemia-reperfusion injury in rats by inhibiting tumor necrosis factor alpha.[J].2006,38(9).
- [3]Umeadi C,Kandeel F,Al-Abdullah IH.Ulinastatin is a novel protease inhibitor and neutral protease activator.[J].2008,40(2).
- [4]Tatsuo Tanita,Chun Song,Hiroshi Kubo,etc.Superoxide anion mediates pulmonary vascular permeability caused by neutrophils in cardiopulmonary bypass[J].1999,29(8).