Abstract： Objective To compare two different methods of anesthesia for intracranial aneurysm surgery inervention,To explore the best methods of anesthesia. Methods Forty patients of ASA Ⅰ～Ⅱ grade intracranial aneurysm surgery, were randomly divided into two groups, each of twenty cases, the same two sets of induction of anesthesia, after intubation, group Ⅰ remifentanil infusion 0.2 ～ 0.4 ug/kg/min, propofol 4 ～6 mg/kg/h maintained, Group H of 2.0%～2.5% inhaled sevoflurane to maintain anesthesia, surgery based on clinical signs such as blood pressure,heart rate, ETCO2 , and other physical activities, at any time adjust the infusion rate and the concentration of inhaled anesthetics, When necessary , Additional Rocuronium 10 ng, Records of patients with surgery to clear the end of time and the end of surgery to extubation time. Awake period of observation of the situation in patients with restless, the follow-up of postoperative and intraoperative known. Results Sober time group Ⅰ (6.9 ± 2.1 ) min, group Ⅱ ( 9.8 ± 3.0 ) min, ( P ＜ 0.05 ), extubation time group Ⅰ (9.0 ±2.7) min, group Ⅱ ( 12 ± 3.8 ) min ( P ＜ 0.05 ), the incidence of restless awake period group Ⅰ 0, group Ⅱ of 30% (6/20) , Postoperative nausea and vomiting incidence was no significant difference in the two groups had no knowledge of surgery. Conclusion Remifentanil combined with propofol infusion for intracranial aneurysm surgery intervention is superior to sevoflurane inhalation anesthesia.