Paper - WANFANG MED ONLINE

You Position: Home > Paper

The Relation between Soft Palate and Obstructive Sleep Apnea-Hypopnea Syndrome

( views:194, downloads:53 )

Author:: No author available

Journal Title:: MEDICAL RECAPITULATE

Issue:: 11

DOI:: 10.3969/j.issn.1006-2084.2010.11.037

Key Word:: 软腭;阻塞性睡眠呼吸暂停低通气综合征;病理

Abstract：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的病因是复杂的和多因素的.大量研究表明,软腭的形态和组织病理学的很多改变都与OSAHS密切相关,软腭后移造成腭帆间隙消失,呼吸道扩张肌的肌纤维分布异常导致的肌肉活动减弱,软腭中脂肪分布增加,肌肉呈现的炎症改变及腭咽部神经纤维的损伤等一系列解剖形态及显微结构上的诸多改变,构成了OSAHS发病机制中的重要环节.但软腭与OSHAS发病更为确切的因果联系,有待于作大规模的临床调查,在分子水平更进一步地研究.

Reference

[1]何春燕,张盛忠,叶京英,等.阻塞性睡眠呼吸暂停低通气综合征患者腭咽肌组织病理学观察[J].2008,(5).
[2]林忠辉,张红蕾,王廷础.阻塞性睡眠呼吸暂停综合征患者上气道MRI观察[J].2000,(1).
[3]倪炳华.阻塞性睡眠呼吸暂停综合征患者手术前后腭咽测量及临床意义[J].2000,(4).
[4]韩德民,叶京英,王军,等.上气道压力测定对阻塞性睡眠呼吸暂停综合征阻塞部位定位诊断研究[J].2001,(4).
[5]李五一,倪道凤,姜鸿.阻塞性睡眠呼吸暂停综合征患者睡眠时咽腔观察[J].1999,(1).
[6]韩德民,叶京英,王军,等.腭帆间隙解剖学研究与腭咽成形术[J].2003,(6).
[7]J R, Wheatley,T C, Amis.Mechanical properties of the upper airway.[J].1998,4(6).
[8]B T, Woodson,J C, Garancis,R J, Toohill.Histopathologic changes in snoring and obstructive sleep apnea syndrome.[J].1991,101.
[9]B, Fleury,C, Hausser-Hauw,F, Chabolle.[Obstructive sleep apnea syndrome and the upper airway muscles].[J].2001,157(11 Pt 2).
[10]M, Blumen,F, Chabolle,E, Rabischong,etc.[Dilator muscles of the pharynx and their implication in the sleep apnea syndrome of obstructive type. Review of the literature].[J].1998,115(2).
[11]Verse T,Paulsen FP,Steven P,etc.Upper airway epithelial structural changes in obstructive sleep-disordered breathing.[J].2002,166(4).
[12]Ariel Schwartz,Reni Sabo,Rivka Gal,etc.Oropharyngeal Fatty Infiltration in Obstructive Sleep Apnea Patients: A Histologic Study[J].1998,107(2).
[13]喻筱红,柳端今,张盛忠.阻塞性睡眠呼吸暂停综合征患者腭咽软组织病理改变[J].1998,(5).
[14]FRIBERG DANIELLE,ANSVED TOR,BORG KRISTIAN,etc.Histological Indications of a Progressive Snorers Disease in an Upper Airway Muscle[J].1998.
[15]K, Olofsson,S, Hellstr?m,M L, Hammarstr?m.Human uvula: characterization of resident leukocytes and local cytokine production.[J].2000,109(5).
[16]Hamans EP,Creten W,De Backer-WA,etc.Morphometric analysis of the uvula in patients with sleep-related breathing disorders.[J].2000,257(4).
[17]Grzegorz, Namys?owski,Wojciech, Scierski,Ewa, Zembala-Nozyńska,etc.[Histopathologic changes of the soft palate in snoring and obstructive sleep apnea syndrome patients].[J].2005,59(1).
[18]Marin Sekosan,Christopher O. Olopade,Barry Wenig,etc.Decrease in Immunoreactive Neutral Endopeptidase in Uvula Epithelium of Patients with Obstructive Sleep Apnea[J].1997,106(6).
[19]Svanborg E.Impact of obstructive apnea syndrome on upper airway respiratory muscles.[J].2005,147(2).
[20]Hokfelt T,Nordlander B,Friberg D,etc.Abnormal afferent nerve endings in the soft palatal mucosa of sleep apnoics and habitual snorers.[J].1997,71(1).
[21]Marc I,Simoneau JA,Gelinas Y,etc.Physiologic, metabolic, and muscle fiber type characteristics of musculus uvulae in sleep apnea hypopnea syndrome and in snorers.[J].1995,95(1).
[22]Petrof BJ,Boyd JH,Kimoff RJ,etc.Upper airway muscle inflammation and denervation changes in obstructive sleep apnea.[J].2004,170(5).
[23]Gilbey P,Hammel I,Ophir D,etc.Histopathology of the uvula and the soft palate in patients with mild, moderate, and severe obstructive sleep apnea.[J].2002,112(2).
[24]Stal PS,Lindman R.Abnormal palatopharyngeal muscle morphology in sleep-disordered breathing.[J].2002,195(1).
[25]L Edstr?m,H Larsson,L Larsson.Neurogenic effects on the palatopharyngeal muscle in patients with obstructive sleep apnoea: a muscle biopsy study.[J].1992,55(10).
[26]Ferretti GR,Mayer P,Veale D,etc.Obstructive sleep apnea syndrome: hooked appearance of the soft palate in awake patients--cephalometric and CT findings.[J].1999,210(1).