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Research progress in the relationship between cell immortalization and carcinogenesis
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- Author:
- No author available
- Issue:
- 45
- DOI:
- 10.3969/j.issn.1673-8225.2010.45.031
- Key Word:
- 永生化细胞;肿瘤细胞;形成;DNA永生化链;肿瘤干细胞;综述文献
Abstract： 背景:永生化细胞和肿瘤细胞在基因表达水平、蛋白水平及表型水平等方面存在诸多区别和联系,目前对两种细胞之间关系的认识仍存在争议.目的:分析永生化细胞与肿瘤细胞之间的关系,总结肿瘤细胞生成有关理论的研究进展和前景.方法:应用计算机检索PubMed数据库和SpringerLink数据库(2001-01/2010-01),以"cellular immortality,cancer mechanism"为检索词.应用计算机检索中国知网数据库(2001-01/2010-01),以"细胞永生化、癌变机制"为检索词.结果与结论:共收集95篇文献,中文35篇,英文60篇.排除发表时间较早、重复及类似研究,最终应用文献41篇.永生化细胞不是肿瘤细胞,普遍认为细胞永生化是细胞癌变过程中的必经阶段,若是如此,肿瘤细胞应易于培养.而实际上肿瘤细胞初代培养时非常困难,因此有的学者就二者之间的关系提出质疑.目前有关肿瘤细胞生成的理论存在非整倍体假说、DNA永生化链假说、肿瘤干细胞假说等.对二者之间关系的进一步研究,有利于永生化细胞的应用及肿瘤的治疗.
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