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Expression of estrogen receptor alpha in different cerebral regions of rats with fimbria/fornix transection
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF CLINICAL REHABILITATION
- Issue:
- 41
- DOI:
- 10.3321/j.issn:1673-8225.2005.41.050
- Key Word:
- 受体,雌激素;脑;疾病模型,动物
Abstract： 目的:观察穹窿海马伞切断大鼠不同脑区雌激素受体α表达的变化,了解穹窿海马伞切断对雌激素受体α表达的影响.方法:实验于2003-03/12在青岛大学医学院附属医院脑病防治重点实验室完成.取成年健康雌性Wistar大鼠14只随机分为模型组和对照组,每组7只.模型组大鼠切断双侧穹窿海马伞,对照组不切断穹窿海马伞.所有大鼠术后第28天麻醉状态下处死,取脑组织行雌激素受体α免疫细胞化学染色,观察脑海马CA1区、皮质区、杏仁复合体区、基底前脑Meynert核等部位雌激素受体α阳性细胞表达变化.结果:14只大鼠全部进入结果分析.模型组大脑皮质区和基底前脑Meynert核区雌激素受体α阳性细胞数显著少于对照组[(25.71±1.11),(58.69±30.26)个;(3.31±1.11),(52.31±22.52)个,P＜0.01];脑海马CA1区和杏仁复合体区雌激素受体α阳性细胞数与对照组比较无差异(P＞0.05).结论:穹窿海马伞切断导致大鼠皮质区和基底前脑Meynert核区雌激素受体α表达减少,这种病理变化可能与基底前脑Meynert核到皮质的胆碱能神经蜕变有关.
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