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Changes of neuropeptide Y and atrial natriuretic peptide in a rat model of cerebral vascular spasm induced by subarachnoid hemorrhage
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF CLINICAL REHABILITATION
- Issue:
- 19
- DOI:
- 10.3321/j.issn:1673-8225.2004.19.045
- Key Word:
- 蛛网膜下腔出血;脑缺血,暂时性;神经肽Y;心钠素
Abstract： 目的:探讨神经肽类物质在蛛网膜下腔出血(subarachnoid hemorrhage,SAH)后脑血管痉挛中的作用机制,为寻找有效的防治脑血管痉挛的方法提供理论基础.方法:20只Wistar大鼠被随机分为正常对照组及单纯注血组,通过枕小脑延髓池注血法建立蛛网膜下腔出血模型,根据临床症状和体征及皮质脑血流量的变化来判定脑血管痉挛的程度,采用放射免疫法动态观察实验性大鼠蛛网膜下腔出血脑血管痉挛血浆、脑脊液中神经肽Y、心钠素含量的变化.结果:注血组大鼠注血前及注血后30 min,2,4,7 d血浆中神经肽Y和心钠素含量分别为(216.61±14.17,321.37±10.10,373.60±13.98,435.05±13.81,558.42±22.60)ng/L和(140.43±3.76,142.39±3.87,175.34±6.21,227.00±10.62,321.19±11.63)ng/L,注血组大鼠注血前及注血后2,4,7 d脑脊液中神经肽Y和心钠素含量分别为(264.71±14.60,523.73±28.33,841.14±35.29,1 036.74±82.39)ng/L和(32.75±2.48,69.35±2.09,143.29±10.23,192.47±9.93)ng/L,注血组血浆、脑脊液中神经肽Y、心钠素含量明显高于同期正常对照组(P＜0.01),且组内不同时间比较差异有显著性意义(P＜0.01).结论:蛛网膜下腔出血后脑血管痉挛是常见的并发症,神经肽Y是继发脑血管痉挛重要的血管活性物质之一.
- [1]冯殿福,温艳茹.经颅多普勒对蛛网膜下腔出血脑血管痉挛状况的评价作用[J].2003,(19).
- [2]屈传强,郭洪志.蛛网膜下腔出血后心钠素的变化及意义[J].2003,(1).
- [3]宁燕,刘学源,陈玉娟,等.老年急性脑梗死患者血浆内皮素、心钠素的动态变化及其临床意义[J].2003,(5).
- [4]徐优芬,蓝穗新,黄源,等.急性心脑血管疾病的血浆神经肽研究[J].2003,(3).
- [5]杨慧英,刘坤玲,韩敏.经颅多普勒超声检查对脑外伤后脑血管痉挛与预后的相关性评价[J].2002,(14).
- [6]许志强,蒋晓江,陈曼娥,等.脑出血大鼠脑组织神经肽Y水平的变化[J].2003,(19).
- [7]L, Edvinsson,H, Hara,R, Uddman.Retrograde tracing of nerve fibers to the rat middle cerebral artery with true blue: colocalization with different peptides.[J].1989,9(2).
- [8]Y, Suzuki,S, Satoh,I, Ikegaki,etc.Effects of neuropeptide Y and calcitonin gene-related peptide on local cerebral blood flow in rat striatum.[J].1989,9(3).
- [9]代佳平,冯华,刘昕.大鼠蛛网膜下腔出血后脑血管痉挛模型的制备[J].2000,(3).
- [10]C, Han,P W, Abel.Neuropeptide Y potentiates contraction and inhibits relaxation of rabbit coronary arteries.[J].1987,9(6).