Single nucleotide polymorphisms in the 3′region of vitamin D receptor gene and the genetic risk of prostate cancer in Chinese population
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF CLINICAL REHABILITATION
- Issue:
- 17
- DOI:
- 10.3321/j.issn:1673-8225.2004.17.062
- Key Word:
- 前列腺肿瘤;维生素D受体;基因;单核苷酸多态;遗传学;These data suggest that there is no significant association between VDRG 3' polymorphisms and prostate cancer in Chinese population;but VDRG polymorphisms may play an important role in forecasting the progression of prostate cancer. The distributions of
Abstract： BACKGROUND: There is a significant difference in the incidence of prostate cancer among different ethnic groups. Recently, some research papers have demonstrated that there is a relatability between vitamin D receptor gene (VDRG) single nucleotide polymorphism (SNP) and prostate cancer, but most are concentrated in high-risk West population.OBJECTIVE: This study aimed at investigating any association between vitamin D receptor gene(VDRG) single nucleotide polymorphism(SNP) and prostate cancer in low-risk Chinese population and the possible reason caused by the racial differences.DESIGN: A nonrandomized controlled research was conducted.SETTING and PARTICIPANTS: The peripheral blood samples of 329persons including 103 prostate cancer cases, 112 benign prostatic hyperplasia cases and 114 controlled cases were gathered from First Hospital of Peking University. All of the people were Han people of northern China, who had known the fact and agreed.INTERVENTION: Case-control study was carried out on 103 prostate cancer patients, 112 benign prostatic hyperplasia and 114 male age-matched controls in populations of northern China. Genotyping methods for the three SNP in the 3′region of VDRG, TaqI, BsmI and Apal included polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and denaturing high performance liquid chromatography(DHPLC).MAlN OUTCOME MEASURE: The distribution of the three SNP in the 3′region of VDRG, TaqI, BsmI and ApaI in the case group and the control group. The relationships between the distribution of VDRG SNP and the dangerous incidence and development of carcinoma of prostate in Han people of China.RESULTS: Genotype and allele frequencies of the 3′region of VDRG polymorphism showed no significant difference in prostate cancer(P ＞0.05 ). However, the distributions of genotype frequencies of BsmI and TaqI differ greatly from the high-risk populations of prostate cancer. The frequency of the AA and Aa genotype and Tt was significantly higher among prostate cancer patients with local disease(T1 -T2) as compared with control group ( P ＜ 0.05 ) . The frequency of genotype AA and Aa were statistically higher in low classified group(Gleason ＜ 7) as compared with control group ( P = 0. 031 ).
- [1]Tayeb MT,Haites NE,Murray GI,etc.CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia.[J].2003,88(6).
- [2]J D, Taylor,T M, Holmes,G M, Swanson.Descriptive epidemiology of prostate cancer in metropolitan Detroit.[J].1994,73(6).
- [3]Dvornyk V,Zhao LJ,Huang QR,etc.Differentiation of Caucasians and Chinese at bone mass candidate genes: implication for ethnic difference of bone mass.[J].2003,67(Pt.3).
- [4]Coetzee GA,Ross RK,Irvine RA,etc.Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor.[J].1997,89(2).
- [5]J A, Taylor,A, Hirvonen,M, Watson,etc.Association of prostate cancer with vitamin D receptor gene polymorphism.[J].1996,56(18).
- [6]Tao G,Wu Q,Gao Y,etc.Studies on the frequencies of vitamin D receptor gene polymorphism in postmenopausal women of Han and Kazak nationality in China.[J].2001,19(5).
- [7]T, Hamasaki,H, Inatomi,T, Katoh,etc.Significance of vitamin D receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in Japanese.[J].2002,68(4).
- [8]J, Ma,M J, Stampfer,P H, Gann,etc.Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians.[J].1998,7.
- [9]Yilmazer S,AlagOl F,Kahraman H.Lack of association between vitamin D receptor gene polymorphism (BsmI) and osteomalacia.[J].2003,22(1).
- [10]Gsur A,Madersbacher S,Haidinger G,etc.Vitamin D receptor gene polymorphism and prostate cancer risk.[J].2002,51(1).
- [11]Jung Gu Kim,Jae Hee Kwon,Seok Hyun Kim,etc.Association between vitamin D receptor gene haplotypes and bone mass in postmenopausal Korean women[J].2003,189(5).
- [12]Vasconcelos A,Pinto D,Lopes C,etc.The role of vitamin D receptor gene polymorphisms in the susceptibility to prostate cancer of a southern European population.[J].2002,47(8).