You Position: Home > Paper
Synthesis of imidapril hydrochloride
( views:0, downloads:0 )
- Author:
- No author available
- Journal Title:
- Modern Chemical Industry
- Issue:
- z1
- DOI:
- No doi available
- Key Word:
- 盐酸咪达普利;血管紧张素转换酶抑制剂;合成
Abstract： N-苄氧羰基-L-天冬酰胺经环化、酯化、甲基化,脱苄氧羰基得到关键中间体(4S)-1-甲基-2-氧代咪唑啉-4-羧酸叔丁酯.再与由N-[ (S) -1-乙氧羰基-3-苯丙基]-L-丙氨酸进行酰化反应,利用氯化氢脱去叔丁基,得到咪达普利盐酸盐,总收率约为26％(以N-苄氧羰基-L-天冬酰胺计).
- [1]王引利,王伟,杜传礼.咪达普利的药理学特性和临床治疗意义[J].2005,(1).
- [2]浙江工业大学.N－[1(S)－乙氧羰基－3－苯丙基]－L－丙氨酸－N－羧酸酐的化学合成方法[P].2003.
- [3]王吉云,胡大一.较高选择性ACE抑制剂--咪达普利[J].2000,(3).
- [4]Doyle MP.,Bailey AS.,Dwyer MP.,etc.ENANTIOSELECTIVE INTRAMOLECULAR CYCLOPROPANATIONS OF ALLYLIC AND HOMOALLYLIC DIAZOACETATES AND DIAZOACETAMIDES USING CHIRAL DIRHODIUM(II) CARBOXAMIDE CATALYSTS [Review][J].1995,117(21).
- [5]田边制药株式会社.制备旋光性2-氧代咪唑烷衍生物的方法[P].1989.
- [6]Kimiaki Hayashi,Kenichi Nunami,Jyoji Kato,etc.Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives[J].1989,32(2).
- [7]浙江华海药业股份有限公司,中国科学院成都有机化学有限公司.一种制备咪达普利中间体2-氧代咪唑烷衍生物的方法[P].2007.
- [8]常晓时.抗高血压药 盐酸伊米普利[J].1993,014 (4).