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Effects of different volatile anesthetics on cerebral glucose metabolism rate in human
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- Author:
- No author available
- Journal Title:
- THE JOURNAL OF PRACTICAL MEDICINE
- Issue:
- 23
- DOI:
- 10.3969/j.issn.1006-5725.2005.23.009
- Key Word:
- 异氟醚;恩氟烷;氟脱氧葡萄糖F18;正电子发射断层扫描;脑;葡萄糖;代谢率
Abstract： 目的:应用正电子发射断层扫描技术(PET),研究吸入异氟醚和安氟醚麻醉对健康志愿者脑内葡萄糖代谢率(CMRglu)的影响.方法:选择8名志愿者,每位志愿者分别做3次PET扫描,采用PHILIPS CPET Plus扫描仪及18FDG标记技术测定CMRglu,第1次在清醒状态下扫描作为对照,第2、3次分别吸入异氟醚和安氟醚麻醉直至意识丧失.结果:清醒时全脑CMRglu平均为(30.0±1.1)μmol/(100 mg·min),与清醒时比较,异氟醚麻醉降低全脑CMRglu 22%至(23.3±1.4)μmol/(100 mg·min)(P<0.05),安氟醚麻醉降低全脑CMRglu 19%至(24.4±0.9)μmol/(100 mg·min)(P<0.05);吸入异氟醚或安氟醚麻醉后脑内局部葡萄糖代谢率(rCMRglu)均显著降低,其中异氟醚麻醉下以丘脑、舌回和扣带回葡萄糖代谢率降低更为显著(P<0.01);而安氟醚麻醉下丘脑、舌回、扣带回、额叶和桥脑等脑区葡萄糖代谢率的降低最显著(P<0.01).结论:全脑及脑内局部葡萄糖代谢率在吸入异氟醚和安氟醚麻醉时均可显著降低,异氟醚和安氟醚麻醉在人脑内的靶区有一定的相似性,但不完全相同.
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