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谷氨酰胺对危重患者肠道保护作用研究进展
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- Author:
- No author available
- Journal Title:
- THE JOURNAL OF PRACTICAL MEDICINE
- Issue:
- 20
- DOI:
- 10.3969/j.issn.1006-5725.2005.20.063
- Key Word:
- No keyword available
Abstract： @@ 肠道是人体最大的细菌库,肠道黏膜是抵御细菌入侵的重要屏障且极易受损伤.危重患者由于缺氧、感染、应激等各种刺激使肠道屏障改变、通透性增高、肠道免疫功能抑制、肠内细菌和毒素移位,参与多器官功能障碍综合征 (MODS)的发病,故肠道被认为是危重病应激的"中心器官"和 MODS的"始动器" (gut motor)[1].因此 ,采取各种措施保护患者的肠道功能,是危重病医学一项重要任务.
- [1]彭曦,陈蓉春,王裴,等.谷氨酰胺对烧伤大鼠肠上皮细胞线粒体呼吸功能的影响[J].2004,(2).
- [2]彭曦,陈蓉春,王裴,等.谷氨酰胺对烧伤大鼠肠三叶因子表达的影响[J].2004,(3).
- [3]朱明炜,肖路延,刘蕾,等.谷氨酰胺颗粒剂在健康人体的药代动力学研究[J].2003,(2).
- [4]O. Miralles-barrachina,G. Savoye,L. Belmonte-Zalar,etc.Low levels of glutathione in endoscopic biopsies ofpatients with Crohn's colitis: the role of malnutrition[J].1999,18(5).
- [5]U B, Fl?ring,O E, Rooyackers,J, Wernerman,etc.Glutamine attenuates post-traumatic glutathione depletion in human muscle.[J].2003,104(3).
- [6]Jiang ZM,Wang XR,Wilmore D,etc.The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burns: a randomized, double-blind, controlled clinical trial.[J].2003,27(4).
- [7]Kudsk KA,Fukatsu K,Johnson CD,etc.Glutamine-enriched total parenteral nutrition maintains intestinal interleukin-4 and mucosal immunoglobulin A levels.[J].2000,24(5).
- [8]Chwals WJ.Regulation of the cellular and physiological effects of glutamine.[J].2004,4(8).
- [9]Coeffier M,Dechelotte P.The role of glutamine in intensive care unit patients: mechanisms of action and clinical outcome.[J].2005,63(2).
- [10]Melis GC,ter Wengel N,van Leeuwen PA,etc.Glutamine: recent developments in research on the clinical significance of glutamine.[J].2004,7(1).
- [11]Shimizu Y,Wasa M,Fukuzawa M,etc.Glutamine stimulates amino acid transport during ischemia-reperfusion in human intestinal epithelial cells.[J].2005,123(1).
- [12]N, Manhart,K, Vierlinger,A, Spittler,etc.Oral feeding with glutamine prevents lymphocyte and glutathione depletion of Peyer's patches in endotoxemic mice.[J].2001,234(1).
- [13]Labow BI,Souba WW.Glutamine.[J].2000,24(12).
- [14]Frantisek, Novak,Daren K, Heyland,Alison, Avenell,etc.Glutamine supplementation in serious illness: a systematic review of the evidence.[J].2002,30(9).
- [15]Curi R,Lagranha CJ,Doi SQ,etc.Molecular mechanisms of glutamine action.[J].2005,204(2).
- [16]Tazuke Y,Shimizu Y,Wang HS,etc.Alanyl-glutamine-supplemented parenteral nutrition prevents intestinal ischemia-reperfusion injury in rats.[J].2003,27(2).
- [17]BISCHOFF S,RIFAI K,OCKENGA J.Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis.[J].2002,21(5).
- [18]Olasunkanmi A J, Adegoke,Michael I, McBurney,Susan E, Samuels,etc.Modulation of intestinal protein synthesis and protease mRNA by luminal and systemic nutrients.[J].2003,284(6).