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ICAM-1在兔无心跳供体肺移植术后的表达及意义
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- Author:
- No author available
- Journal Title:
- SHANDONG MEDICAL JOURNAL
- Issue:
- 48
- DOI:
- 10.3969/j.issn.1002-266X.2008.48.020
- Key Word:
- 肺移植;无心跳供体;缺血再灌注;细胞间黏附分子
Abstract： 将30只拟行肺移植术的大白兔随机分三组,每组5对分别为供受体.一组为有心跳供体肺(HBD组),另两组供体肺分别为无心跳供体热缺血30 min (NHBD-30组)及60 min (NHBD-60组);另选15只作为对照组.建立兔无心跳供体左单肺肺移植模型,切除的受体左肺作为对照,采用免疫组化法检测供体肺缺血期间和移植再灌注肺组织内皮细胞间黏附分子-1(ICAM-1)表达水平.结果 与HBD组、NHBD-30组比较,NHBD-60组左肺移植再灌注后肺泡区、小动脉区ICAM-1表达明显上调(P＜0.05);与对照组比较,三组右肺冷保存10 h后无显著差异,与NHBD-60组左肺移植再灌注后比较均有显著差异(P＜0.05).认为无心跳供体肺短时间热缺血未造成严重肺组织损伤,未能触发ICAM-1表达明显上调;ICAM-1表达上调发生于再灌注期间.
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