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心脑血管疾病患者发生阿司匹林抵抗现象的相关研究
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- Author:
- No author available
- Journal Title:
- SHANDONG MEDICAL JOURNAL
- Issue:
- 28
- DOI:
- 10.3969/j.issn.1002-266X.2005.28.020
- Key Word:
- 心脑血管疾病;阿司匹林;血小板聚集;血栓烷B2
Abstract： 门诊筛选具有阿司匹林(ASA)预防适应证的患者200例,服用ASA前后抽取静脉血,分别用二磷酸腺苷(ADP)、花生四烯酸(AA)诱导血小板凝集试验(PAgT),检测血小板聚集率及血栓烷B2(TXB2)水平.结果患者中阿司匹林抵抗(AR)发生率为4.5%,阿司匹林半敏感(ASR)20.7%,AR及ASR患者中女性比率较阿司匹林敏感(AS)者高(P＜0.05),吸烟者少(P＜0.01);TXB2水平与AA、ADP诱导的血小板聚集率有较好的相关性.AA、ADP诱导的血小板聚集率、TXB2水平测定可作为口服ASA疗效监测的手段.
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