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Study of Th1/Th2 cytokines and pro-inflammatory cytokines in tuberculosis patients
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- Author:
- No author available
- Journal Title:
- SHANDONG MEDICAL JOURNAL
- Issue:
- 28
- DOI:
- 10.3969/j.issn.1002-266X.2005.28.006
- Key Word:
- 结核;细胞因子;前炎性因子;鉴别诊断
Abstract： 目的研究结核患者细胞因子变化规律和调控机制,以帮助临床鉴别诊断.方法对54例结核患者、18例肺癌患者和12例健康人血清、肺泡灌洗液、胸水及脑脊液等多种标本的各种细胞因子进行检测.结果结核患者血清白介素(IL)-12、IL-18等Th1细胞因子及IL-10、IL-4等Th2细胞因子水平均较高.各种细胞因子在脑脊液中含量均较低;干扰素γ(IFN-γ)在胸水渗出液中含量很高.前炎性因子IL-6、IL-8和肿瘤坏死因子-α(TNF-α)在结核患者中水平较高.IL-10与TNF-α的比值在结核和肿瘤患者之间有显著差异.结论细胞因子检测有助于结核病和肺癌患者的鉴别诊断.
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