Abstract： Primary angle-closure glaucoma(PACG)is a common cause of blindness,and angle closure is a fundamental pathologic process in PACG.With the development of ophthalmic equipment,the pathogenesis of PACG has been better understood.In addition to the traditional mechanisms of pupillary block and plateau iris,it has been found that its pathogenesis is not only related to abnormal ocular anatomy,but also more closely related to ocular dynamics,genetic factors.and psychophysiologic stressors.This article summarizes the pathogenesis and risk factors of PACG in conjunction with literature reports,with a view to providing guidance for clinical work and useful theoretical support for early diagnosis and treatment options for glaucoma.