Abstract： AIM:To observe the effects of Liuwei Dihuang Tang on the expression levels of ferritin,recombinant solute carrier family 7 member 11(SLC7A11),glutathione(GSH),and glutathione peroxidase 4(GPX4)in retinal of aging model rats.METHODS:A total of 45 SD rats were randomly divided into a blank group,a model group,and a traditional Chinese medicine(TCM)group,with 15 rats in each group.The blank group was intraperitoneally injected with physiological saline,while the model group and TCM group were intraperitoneally injected with D-galactose[500 mg/(kg·d)].At the same time,the TCM group was orally administered with Liuwei Dihuang Tang[6.75 g/(kg·d)],while the blank group and model group were orally administered with equal volume of physiological saline for 8 consecutive wk.The expression levels of ferritin,SLC7A11,GSH,and GPX4 in the retinal tissues of rats in each group were detected.RESULTS:The expression of ferritin in the retinal tissue of the model group was increased compared to the blank group(P＜0.05),while the expression of GSH,SLC7A11,and GPX4 was reduced(P＜0.05).The expression of GSH,SLC7A11,and GPX4 in the retina tissue of rats in the TCM group was higher than that in the model group(P＜0.05).CONCLUSIONS:Liuwei Dihuang Tang may exert a delaying effect on retinal aging by regulating the ferroptosis pathway.