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Clinical study on evolvement of T cell activation of acquired immunodeficiency syndrome with disease progression
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF INTERNAL MEDICINE
- Issue:
- 11
- DOI:
- No doi available
- Key Word:
- 人类免疫缺陷病毒;艾滋病;免疫活化
Abstract： 目的 探讨HIV/AIDS外周血T淋巴细胞活化水平与病情进展的关系.方法 检测105例HIV/AIDS患者外周血可溶性CD27(sCD27)水平,CD28+CD8+、CD28+CD4+、HLA-DRCD8+和CD38+CD8+比例以及CD4+T淋巴细胞计数,并在正常体检人群中随机抽取15名健康人作为对照组.分别用流式细胞技术和ELISA方法检测和分析T细胞活化指标(CD2+CD8+、CD28+CD4+、CD38+CD8+、HLA-DRCD8+、sCD27)与疾病分期、CD4+T淋巴细胞计数的相关性.结果 HIV/AIDS的sCD27水平和HLA-DRCD8+和CD38+CD8+比例较正常人显著升高(P＜0.05),sCD27在AIDS C3期患者中明显升高,与B3期患者比较有显著性差异,CD28+CD4+、CD28+CD8+、HLA-DRCD8+和CD38+CD8+比例在CD4+T淋巴细胞计数超过200/ul的患者中显著升高(P＜0.05).结论 T淋巴细胞活化水平与AIDS病情进展密切相关,HIV/AIDS的T淋巴细胞活化水平明显升高,CD4+T淋巴细胞计数超过200/μl患者的T淋巴细胞活化水平高于CD4+T淋巴细胞计数低于200/μl的患者.
- [1]汪习成,吴昊,李太生,等.HIV/AIDS患者CD28在外周血CD4+、CD8+ T细胞上的表达变化[J].2003,(9).
- [2]周华英,赖力英,朱映华,等.淋巴细胞CD28分子和sCD27在抗HIV-1治疗中的变化及其临床意义[J].2005,(11).
- [3]周华英.HAART和HIV感染的免疫重建[J].2005,(5).
- [4]郝秀丽,张逢春.CD28分子的研究进展[J].2004,(2).
- [5]汪习成,吴昊,李太生,等.HIV感染者/AIDS患者外周血CD38 HLA-DR分子在CD4+ CD8+T淋巴细胞上的表达[J].2003,(1).
- [6]M. LEVACHER,F. HULSTAERT,S. TALLET,etc.The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value[J].1992,90(3).
- [7]Rossio, J. L.,Bess, J.,Henderson, L. E.,etc.HLA Class II on HIV Particles Is Functional in Superantigen Presentation to Human T Cells: Implications for HIV Pathogenesis[J].1995,11(12).
- [8]A, Funaro,G C, Spagnoli,C M, Ausiello,etc.Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation.[J].1990,145(8).
- [9]Martin JN,Sinclair E,Hunt PW,etc.T Cell Activation Is Associated with Lower CD4+ T Cell Gains in Human Immunodeficiency Virus-Infected Patients with Sustained Viral Suppression during Antiretroviral Therapy.[J].2003,187(10).
- [10]Haase AT.Perils at mucosal front lines for HIV and SIV and their hosts.[J].2005,5(10).
- [11]B E, Tomkinson,D K, Wagner,D L, Nelson,etc.Activated lymphocytes during acute Epstein-Barr virus infection.[J].1987,139(11).
- [12]A, van Es,W M, Baldwin,P J, Oljans,etc.Expression of HLA-DR on T lymphocytes following renal transplantation, and association with graft-rejection episodes and cytomegalovirus infection.[J].1984,37(1).
- [13]R, Cantin,J F, Fortin,G, Lamontagne,etc.The acquisition of host-derived major histocompatibility complex class II glycoproteins by human immunodeficiency virus type 1 accelerates the process of virus entry and infection in human T-lymphoid cells.[J].1997,90(3).
- [14]Hallahan CW,Sanford C,Loutfy M,etc.Relationship between the frequency of HIV-specific CD8(+) T cells and the level of CD38(+)CD8(+) T cells in untreated HIV-infected individuals[J].2004,101(8).
- [15]CASTILLETTI C.,CAPOBIANCHI M.R.,FAIS S.,etc.HIV Type 1 Grown on Interferon\u03b3-Treated U937 Cells Shows Selective Increase in Virion-Associated Intercellular Adhesion Molecule 1 and HLA-DR and Enhanced Infectivity for CD4-Negative Cells[J].1995.
- [16]Barbour JD,Deeks SG,Segal MR,etc.Evolution of Phenotypic Drug Susceptibility and Viral Replication Capacity during Long-Term Virologic Failure of Protease Inhibitor Therapy in Human Immunodeficiency Virus-Infected Adults.[J].2002,76(21).
- [17]龚非力 熊思东.医学免疫学（第2版）[M].2007.