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Acute toxicity of diphenylchlorarsine in mice and rats
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- Author:
- No author available
- Journal Title:
- ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE
- Issue:
- 20
- DOI:
- 10.3321/j.issn:1000-5404.2006.20.007
- Key Word:
- 二苯氯胂;灌胃法染毒;半数致死剂量;急性毒性
Abstract： 目的 评估日本遗弃在华化学武器二苯氯胂(diphenylchlorarsine, DA)对环境和人畜的毒性危害.方法 通过DA对小白鼠灌胃,观察小白鼠的中毒症状,测定DA对小白鼠的LD50值;观察DA对大鼠皮肤和眼睛的刺激作用.结果 DA对小白鼠的LD50为28.07 mg/kg;对大鼠皮肤的最大无作用剂量为8.8 mg/ml(0.44 mg);对眼睛损伤的最大无作用剂量为0.7 mg/ml (0.014 mg).结论 DA可造成小鼠肝、肾、胃和食道器质性的损伤,高浓度的DA可引发大鼠皮肤炎症和眼睛晶状体混浊,严重时引起失明.
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